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KMID : 1007520080170030675
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Food Science and Biotechnology
2008 Volume.17 No. 3 p.675 ~ p.678
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Comparison of the Permeability of Stilbene Analogues in Caco-2 Cells
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Kim Su-Na
Ahn Ji-Yun
Shon Dong-Wha
Kim Ji-Sun
Kim Mi-Hye
Ha Tae-Youl
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Abstract
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Permeability of resveratrol, piceid, rhapontigenin, and rhaponticin in Caco-2 cell assays using high-performance liquid chromatography were compared. Caco-2 cell monolayers were used to evaluate the transport rates of stilbene analogues from the apical to the basolateral sides. All stilbenes experimented in this study were transported to the basolateral side by times. For comparing the permeability of 4 stilbenes, we calculated the slope of the cumulative concentration of each stilbene in basolateral sides over time, resulting in those values of resveratrol, piceid, rhapontigenin, and rhaponticin with 3.766×10?5, 4.330×10?6, 5.430×10?5, and 2.458×10?5 ?M/sec, respectively. Apparent permeability coefficient of resveratrol and rhapontigenin were calculated to 9.994×10?6 and 1.441×10?6 cm/sec, respectively, while those of piceid and rhaponticin were to 1.149×10?7 and 6.523×10?7 cm/sec, respectively. These results suggest that aglycones would be absorbed more effectively than glycosides in stilbenoids.
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KEYWORD
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Caco-2 cell, resveratrol, piceid, rhapontigenin, rhaponticin
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